The goal of implementation science is to establish the complex components necessary to achieve high-quality, long-term outcomes for recipients of human services. The practice of implementation involves putting these components into action. Across a multitude of domains such as human services, health services, and education, evidence supports purposeful, active, and effective approaches to implementation, organization change, and system transformation. Organizing implementation research into a common knowledge-base and establishing multi-disciplinary communities that will use and expand this knowledge can benefit children, families, adults, communities, and societies around the globe. In July 2011, the first biennial Global Implementation Conference will bring together the most knowledgeable and active people in the field to advance the practice and science of implementation.